TFcancer: a manually curated database of transcription factors associated
with human cancer
Qingqing Huang1, Zhengtang Tan1, Yanjing Li1, Wenzhu Wang1, Mei Lang1, Changying Li1, Zhiyun Guo1*
1. School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
Abstract
Summary: Transcription factors (TFs) are critical regulation elements and its dysregulation can lead to a variety of cancers. However, currently, there are no such online resources for large-scale collection, storage and analysis of TF-cancer associations in those cancers. To fill this gap, we present a database called TFcancer (http://lcbb.swjtu.edu.cn/tfcancer/), which contains 3,136 experimentally supported associations between 364 TFs and 33 TCGA cancers by manually curating more than 1,800 literature. TFcancer mainly concentrates on four aspects: TF expression, molecular alteration, regulatory relationships between TFs and target genes, and biological processes and signaling pathways of TFs in cancers. TFcancer not only provides a user-friendly interface for browsing and searching but also allows flexible data downloading and user data submitting. It is believed that TFcancer is a helpful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of TFs involved in human cancers.
